o:1085 Morfometrijska i imunohistohemijska analiza somatotropnih ćelija adenohipofize i njihova povezanost sa prisustvom sarkopenije tokom starenja čoveka Morphometric and immunohistochemical analysis of somatotropic cells in the adenohypophysis and their association with the sarcopenia during human aging : doctoral dissertation sr The process of aging is associated with changes in all organs and systems of the human body. It is believed that there is a relationsip between a reduced secretion of growth hormone from somatotropic adenohypophyseal cells and loss of muscle mass, i.e. sarcopenia in healthy elderly individuals. Having in mind this relationship, this research was focused on the detection and quantification of changes in human sompatotropic cells of the adenohypo-physis and changes in the muscle fibers of the human psoas muscle in the examinees of different age and gender, using immunohistochemical and morphometric analysis (measure-ment of volume density, area, perimeter, and Feret's diameter) in order to get an insight into their dynamics during aging. The results of the study demonstrated a reduction of average volume density of somatotropic cells and volume density of type II muscle fibers with advan-cing age; different dynamics of volume density values of somatotropic cells in individuals of both sexes; drop of average area, perimeter, and Feret's diameter of the same cells with aging; presence of significant differences of the above astereologic parameters between genders; drop of the average nucleocytoplasmic ratio of somatotropic cells with aging; drop of values of astereologic parameters of type I and II muscle fibers in both genders with aging; correlation of stereologic and astereologic parameters of somatotropic cells and age of the analyzed cases, and that the above parameters in combination represent statistically signi-ficant predictors of the respective stereologic and astereologic parameters of type II muscle fibers during aging. Biografija: list 129 Datum odbrane: 06.11.2015. Anatomy 1025413357 91552101 3007 91552100 1025413357 2016-06-24T16:50:37.053Z 45 no 46 mentor Vladimir M. 1985- Antić 2015 63 mentor Ivan Jovanović 2015 63 član komisije Rade Čukuranović 2015 63 član komisije Branislav Filipović 2015 63 član komisije Verica Avramović 2015 63 član komisije Slađana Ugrenović 2015 132 lista 3699300 http://phaidrabg.bg.ac.rs/o:1085 no yes 3 2016-06-24T16:50:37.320Z 70 sarkopenija, somatotropne ćelije, psoasni mišić, mišićna vlakna tip I, mišićna vlakna tip II, morfometrija sarcopenia, somatotropic cells, psoas muscle, type I muscle fibers, type II muscle fibers, morphometrics 612.41.433:612.64-67(043.3) 1738 18A05 2015