o:1153 Morfometrijska i imunohistohemijska analiza udruženosti strukturnih promena sa distribucijom psamoma telašaca u horoidnim pleksusima moždanih komora tokom starenja čoveka Morphometric and immunohistochemic analysis of structural changes in relation to psamomma bodies distribution in cerebral ventricules' choroid plexus with age in humans : doctoral dissertation sr During the ageing process, numerous structural and functional changes occur in the cerebral ventricles’ choroid plexus. The formation of psamomma bodies starts at an early age, and is considered a physiological consequence of the ageing process. Using histochemical and immunohistochemical methods, autopsy samples of choroid plexus of all four cerebral ventricles were analyzed morphologically and morphometrically. The structure of the choroid plexus, its epithelium morphology, as well as the distribution and characteristics of the psamommma bodies, were investigated in this study. Besides, the expression of CD44, CD68, osteopontin and osteocalcin, was analyzed. The results of this study showed significant structural changes in choroid plexus during ageing. Choroid plexus arborification and its blood vessels density is reduced. The epitelium changed with presence of high domed, flattened spindle, or large cells expanded by its content. Psamomma bodies in the elderly formed large groups, often inside cysts, and showed an increse in their number and size. Increased osteopontin expression is characteristic younger population choroid plexus, unlike osteocalcin whose expression progressively increases withe age. Psamomma bodies formation and their characteristics are in correlation with changes in the structure of the choroid plexus and its epithelium, during the ageing process in humans. After taking into consideration the role of choroid plexus in the central nervous system homeostasis regulation, the stated changes in ageing choroid plexus and psamomma bodies characteristics, may contribute to the reveiling of the mechanism of fuctional impairement of the brain in the elderly. Beleška o autoru: str. 203 Datum odbrane: 13.09.2016. Anatomy 1025586669 91552101 4220 91552100 1025586669 2016-11-17T19:16:12.053Z 45 no 46 mentor Vladimir S., 1973- Živković 2016 63 mentor Rade Čukuranović 2016 63 član komisije Ivan 1970- Jovanović 2016 63 član komisije Branislav 1962- Filipović 2016 203 str. 6388259 http://phaidrabg.bg.ac.rs/o:1153 no yes 4 2016-11-17T19:16:12.320Z 70 psamomatozna telašca, horoidni pleksus, starenje, histohemija, imunohistohemija, morfometrija, CD44, CD68, osteopontin, osteokalcin psamomma bodies, choroid plexus, ageing, histochemistry, immunohistochemistry, morphometry, CD44, CD68, osteopontin, osteocalcin 611.018.8:577.24(043.3) B440 1738 18A05 2016