o:1270 Uticaj odabranih monoterpena na aktivnost dijagnostički značajnijih enzima u kontrolnom humanom serumu in vitro Influence of selected monoterpenes on activity of diagnostically important enzymes in human serum in vitro : doctoral dissertation sr In order to determine the terpenes effect on enzyme activity is been studied the impact of aqueous (prepared manually (I1) or ultrasound (I2) mixing) and DMSO (dimethyl sulfoxide) terpenes solution (carvacrol, linalool, nerol and geraniol) on the activity of creatine kinase, lactate dehydrogenase, alkaline phosphatase, gamma-glutamyl transferase, aspartate aminotransferase and alanine aminotransferase,as well as the impact of the same type of terpenes solution (carvacrol, linalool, nerol, geraniol, β-pinene, myrcene, citral, eucalyptol, terpineol, and eugenol) on the activity of amylase in the control sera (with the normal (N) and increased (H) activity of the ingredients. Measurement of activity was conducted after incubation of the serum sample from the 10 minutes and aqueous solutions of terpenes prepared as I1 or as I2, or solutions of terpenes in DMSO at four concentrations. All the terpenes solutions have demonstrated that the inhibitory effect depends on various parameters: kinds of serum (higher percentage of inhibition in N than the H serum), the type of solvent ( the aqueous solution as I2 and DMSO solutions showed approximately the same percentage of inhibition in both types of serum) and way of preparing the aqueous solutions (a higher percentage of inhibition have the aqueous solution of terpenes as I2 in N serum and as I1 in H serum), as well as on the type of terpenes or enzymes. Statistical data processing all terpenes solution (with the partial exception of neroli and geraniol) confirmed the grouping or by type of serum or by type of solvent or the method of preparation of aqueous solution. Biografija [Ljiljane Jelenković] sa bibliografijom: str. 177-181 Datum odbrane: 29.09.2016. organic chemistry and biochemistry, Practical part of this doctoral thesis was done in Biochemicallaboratory of Health Center in Nis. 1025362921 91552101 4659 91552100 1025362921 2017-03-14T12:49:43.053Z 45 no 46 mentor Ljiljana A. 1967- Jelenković 2016 63 mentor Ivan 1974- Palić 2016 63 član komisije Vesna 1968- Stankov Jovanović 2016 63 član komisije Violeta 1968- Mitić 2016 63 član komisije Milanka Radulović 2016 63 član komisije Tatjana Jevtović Stoimenov 2016 [9], 186 str. 5303968 http://phaidrabg.bg.ac.rs/o:1270 no yes 4 2017-03-14T12:49:43.320Z 70 inhibicija, enzimska aktivnost, klinički enzimi, terpeni,serum, karvakrol, linalol, nerol, geraniol inhibition, enzyme activity, clinical enzymes, terpenes, serum,carvacrol, linalool, nerol, geraniol 547.596 : (612.128 + 612.15 +58.085)(043.3) 1738 18A07 18A0703 2016