o:1372 Kombinatorne biblioteke odabranih prirodnih i sintetskih biološki aktivnih estara Combinatorial libraries of selected natural and synthetic biologically active esters : doctoral dissertation sr Herein, a successful identification and a means of arriving at (milli)gram quantities of the selected natural esters was achieved through the application of a synthetic combinatorial approach (three libraries with 171 constituents in total, among them 121 new compounds). As a result, new secondary metabolites from Achillea falcata L. ((1R*,3S*,5R*)-sabinyl formate and tiglate), Achillea ageratifolia (Sm.) Boiss. subsp. serbica (Nyman) Heimerl ((1R*,3S*,5R*)-sabinyl formate, tiglate, nonanoate and decanoate), Scandix balansae Reut. ex Boiss. (octadecyl valerate), Scandix pecten-veneris L. (esters of isobutanoic acid and n-C15, C17, C21 and C23 alkanols, as well as esters of isovaleric acid and n-C13, C15 and C17 alkanols) and Anthemis segetalis Ten. (eugenyl angelate, 2-methylbutanoate and 3- methylbutanoate) essential-oil samples wеre identified. Also, the combinatorial approach was successful used for a systematical comparison of chemical/biological properties of ferrocene-containing esters and their corresponding phenyl analogs (a library of eighteen (13 new) 2-substituted methyl acetoacetates). The structures of the synthesized esters were spectrally characterized by MS, NMR (1D- and 2D-NMR, as well as, an NMR methodology that employ lanthanide-induced shifts), FTIR and UV-Vis analyses, and in the case of ferrocene-containing compounds by electrochemical (cyclic voltammetry) and X-ray analyse(s). Several esters were shown to be toxic to A. salina, possessed cytotoxic (to two cell lines), AChE inhibitory, antinociceptive and antimicrobial activities. Antinociceptive activity of (1R*,3S*,5R*)-sabinol was two times higher than that of morphine, and the antifungal activity of 2- acetyl-2-(ferrocenylmethyl)-4-methyl-4-pentenoate was comparable to that of nystatin against Candida albicans. 1025474025 91552101 5126 91552100 1025474025 2017-07-19T11:19:31.053Z 45 no 46 mentor Marko Z. 1987- Mladenović 2017 63 mentor Niko 1981- Radulović 2017 63 član komisije Polina 1979- Blagojević 2017 63 član komisije Irena Novaković 2017 63 član komisije Tamara Todorović 2017 63 član komisije Zorica Stojanović-Radić 2017 554 listova 68861019 http://phaidrabg.bg.ac.rs/o:1372 no yes 4 2017-07-19T11:19:31.320Z 70 Organska sinteza, kombinatorne biblioteke estara, etarska ulja,(1R*,3S*,5R*)-sabinol, dugolančani alkoholi, regioizomernialilmetoksifenoli, metil-2-(ferocenilmetil)acetoacetati, metil-2-benzilacetoacetati, biološka/farmakološka aktivnost, QSPR Organic synthesis, combinatorial libraries of esters, (1R*,3S*,5R*)-sabinol, longchainalkanols, regioisomeric allylmethoxyphenols, methyl-2-benzylacetoacetates,methyl-2-(ferrocenylmethyl)acetoacetates, essential oils, biological/pharmacologicalactivity, QSPR 543.632.514.3 + 547.1-3](043.3) P 390 P004 1738 18A07 18A0703 2017