o:1445 Ispitivanje spazmolitičkih, bronhodilatatornih, antioksidativnih i antimikrobnih efekata ekstrakata i etarskog ulja morača (Foeniculum vulgare Miller) Investigation of the spasmolytic, bronchodilatory, antioxidant and antimicrobial effects of the exstracts and essential oil of fennel (Foeniculum vulgare Miller) : doctoral dissertation sr Fennel (Foeniculum vulgare Miller) is used for centuries in traditional medicine. The research was aimed to investigate biological, biochemical and antimicrobial properties of this plant species and its possible medicinal potential. Examination is evaluated by determining the biological activities such as studies of the effects of different extracts and essential oil on the smooth muscles of the small intestine and rat trachea, which is determined by antioxidative and antimicrobial activity. Chemical analysis of extracts and essential oil was also performed. The study is the difference between the spasmolytic activity of essential oils and extracts of the aerial parts fennel, which were collected in three different years. This study showed that extracts, especially essential oil of different kinds of ground parts of the plant showed significant relaxant effect, in spontaneous, as well as the stimulated smooth muscle contraction of trachea and small intestine of rats. The extracts and essential oil of fennel, have shown good antioxidant activity which was determined as the ability of the extracts to bind free radicals (DPPH method) and the ability of extracts and essential oils to prevent lipid peroxidation of β-carotene in the emulsion of β-carotene/linoleic acid. The extracts and essential oil of fennel, showed poor antimicrobial activity which was tested against both Gram (-) and Gram (+) bacteria isolated from the gastrointestinal and respiratory tract. Chemical analysis showed that the differences in the composition of the essential oil and extracts reflect their biological activity. Beleška o autoru: list 171;Prilozi: listovi 166-170 Datum odbrane: null 1025890029 91552101 5617 91552100 1025890029 2018-02-28T12:47:24.053Z 45 no 46 mentor Marija S. 1980- Gočmanac-Ignjatović 2017 63 mentor Suzana Branković 2017 63 član komisije Mirjana Radenković 2017 63 član komisije Dušanka Kitić 2017 63 član komisije Milan Ćirić 2017 63 član komisije Tatjana Mihajlov-Krstev 2017 171 list 3480119 http://phaidrabg.bg.ac.rs/o:1445 no yes 5 2018-02-28T12:47:24.320Z 70 morač, ileum, ekstrakt, etarsko ulje, spazmolitičko dejstvo, traheja, polifenoli, flavonoidi, antioksidativna aktivnost, antimikrobna aktivnost fennel, ileum, extract, essential oil, spasmolytic effect, trachea, polyphenols, flavonoids, antioxidant activity, antimicrobial activity 615.322:582.794.1]:612.33(043.3) 582.794.1:612.33 B 470 1738 18A05 2017