o:1458 Odnos heat shock proteina i markera inflamacije miokarda kod neonatusa The correlation between heat shock proteins and markers of myocardial inflammation in neonates : doctoral dissertation sr Neonatal heart remodeling occurs during delivery. With the hypothesis that this process does not occur in the same way in healthy pregnancies and those complicated with preeclampsia and gestational diabetes, in umbilical cord blood, using ELISA tests, troponin T and I, Glycogen Phosphorylase-BB, Hsp 27 and Hsp 70 concentrations were measured. The obtained concentrations were correlated with fetal and neonatal characteristics and pregnancy, labor and delivery characteristics. Hsp 70 is the most sensitive marker of fetal stress in pregnancies complicated with gestational diabetes, and cTnI and GP-BB in preeclamptic pregnancies. Hsp 70 and GP-BB concentrations increase with increased fetal heart rate during uterus contractions in labor. Fetal stres can be registered by high cTnI concentrations in maternal metabolic syndroms. Fetal stress as a consequence of maternal high blood pressure can be measured through high GP- BB and cTnI concentrations. Higher cTnI concentartions were found in neonates who had prolonged hospitalizations, while higher Hsp 27 concentrations were found in neonates who were hospitalized in neonatal intensive care unit. Hsp 27, Hsp 70, GP- BB, cTnT, cTnI are sensitive markers of the stress of fetal myocardium in pregnancies complicated by gestational diabetes and preeclampsia. Biografija autora: str. 178Bibliografija: str. 149-177 Datum odbrane: 02.06.2017. Neonatology 1025698541 91552101 5806 91552100 1025698541 2018-06-05T13:26:13.053Z 45 no 46 mentor Ana G. 1979- Mrkaić 2017 63 mentor Ivana Stojanović 2017 63 član komisije Ljiljana Pejčić 2017 63 član komisije Dragan Radovanović 2017 63 član komisije Jasmina Popović 2017 63 član komisije Miloš Kostić 2017 183 str. 2775310 http://phaidrabg.bg.ac.rs/o:1458 no yes 4 2018-06-05T13:26:13.320Z 70 Neonatus, Troponini, Glikogen fosforilaza, Hsp 27, Hsp 70, Miokard, Preeklampsija, Gestacijski Dijabetes Neonate, Troponins, Glycogen Phosphorylase, Hsp 27, Hsp 70, Myocardium, Preeclampsia, Gestational Diabetes 616.12-053.13:577.1(043.3) B660 1738 18A05 18A0514 2017