o:1492 Intersticijalne ćelije kahala u gastrointestinalnom traktu pacova sa dijabetesom melitusom izazvanim streptozotocin-nikotinamidom Interstitial cells of cajal in the gastrointestinal tract of rat with streptozotocin-nicotinamide induced diabetes mellitus : doctoral dissertation sr Interstitial cells of Cajal (ICC) are non-neural cells of mesenchymal origin inserted between nerve elements and smooth muscle cells in the gastrointestinal tract (GIT). ICC are necessary for normal function of gastrointestinal (GI) tract and according to their morphology, function and localization, ICC are classified in several subtypes. Certain ICC subtypes serve as source of electrical slow waves which are electrophysiological foundation of peristalsis, while other ICC subtypes are mediators and modulators of enteric motor neurotransmission, mechanoreceptors and are responsible for proper function of GIT sphincters. Mechanism of diabetic gastroenteropathy (DG) is unclear. ICC disorders caused by metabolic changes in diabetes (DM) could explain symptoms of DG (gastroparesis, slow intestinal transit, constipation, fecal incontinence). The aim of research is to determine ICC distribution and morphology in GIТ of rats in control group and rats with streptozotocin-nicotinamide induced DM using immunohistochemical and morphometric methods. The results of doctoral dissertation showed that all ICC subtypes are present in the GIT of the rat, with regional distribution and density differences. In the DM group, there was a significant diffuse loss of all subtypes of ICC in GIT, while the density of nerve structures remained unchanged. Beleška o autoru: list [152];Bibliografija: listovi 135-151 Datum odbrane: 05.04.2018. histology and embryology, pathology 1026007021 91552101 5864 91552100 1026007021 2018-07-03T09:57:56.053Z 45 no 46 mentor Aleksandra I. 1979- Veličkov 2018 63 mentor Goran Radenković 2018 63 predsednik komisije Verica Avramović 2018 63 član komisije Dušan Sokolović 2018 63 član komisije Dragan Mihailović 2018 63 član komisije Dušan Lalošević 2018 151 list 19959196 http://phaidrabg.bg.ac.rs/o:1492 no yes 4 2018-07-03T09:57:56.320Z 70 Intersticijalne ćelije Kahala, dijabetes melitus,gastrointestinalni trakt, streptozotocin, nikotinamid Interstitial cells of Cajal, diabetes mellitus, gastro intestinal tract,streptozotocin, nicotinamide 611.018.1:616.379-008.64:616.33/34-008.1(043.3) B440; B480; B 520; B 550 1738 18A05 18A0514 2018