o:1498 Značaj inflamatornih markera i poremećaja sistema hemostaze kod bolesnika sa akutnim pankreatitisom The significance of inflammatory markers and disorders of hemostasis in patients with acute pancreatitis : doctoral dissertation sr A possibility to develop sever systemic complications of acute pancreatitis(AP) demands timely assessment of the severity of the disease in order to make an optimal therapeutic approach and a correct prognosis of the disease. The aim of the study was to establish the role of certain individual inflammatory biomarkers and coagulation parameters in the prediction of AP severity, and also to propose a mathematical formula which allows there combined use for the same purpose. Methods. The prospective study included 92 patients with AP. The patients were divided into groups: mild, moderate and severe AP. Results. Based on the results of Mann-Whitney,s test, it can be concluded that a statistically significant difference between groups A(mild) and B(moderate and severe) for CRP (p<0.05). Using the Wald’s stepwise forward method, a prediction model with CRP, PCT, D-dimer 1, D-dimer 3, fibrinogen 1 and fibrinogen 3 parameters as predictors of the severity of AP has been obtained. The percentage of successful prediction of moderate or severe AP based on this model is 76.9%. Conclusion. The combined analysis of biohumoral markers and coagulation parameters presented in the form a mathematical formula can enable a more accurate, rapid, rational and clinically available prediction of the severity of AP. Bibliografija: listovi 113-146. Datum odbrane: 22.05.2018. Gastroenterology and hepatology 1026062317 91552101 6198 91552100 1026062317 2018-11-22T09:18:22.053Z 45 no 46 mentor Snežana K. Tešić Rajković 2017 63 mentor Biljana 1965- Radovanović-Dinić 2017 63 predsednik komisije Aleksandar Nagorni 2017 63 član komisije Goran Marjanović 2017 63 član komisije Tatjana Jevtović Stimenov 2017 63 član komisije Srđan Đuranović 2017 146 listova 5968309 http://phaidrabg.bg.ac.rs/o:1498 no yes 4 2018-11-22T09:18:22.320Z 70 Akutni pankreatitis, prokalcitonin, C reaktivni protein, D dimer acute pancreatitis, procalcitonin, C reactive protein, D dimer 611.1.37 616.37-002.1-005:577.1(043.3) B 550 1738 18A05 18A0521 2017