o:1535 Analiza faktora koji utiču na racionalno propisivanje lekova kod pacijenata sa bubrežnom insuficijencijom Analysis of factors affecting rational drug prescribing to patients with kidney failure : doctoral dissertation sr Introduction. Prescribing may be inappropriate if the potential benefits outweigh risks, when there are more appropriate alternatives for prescribed drugs or when potentially useful drug was omitted. PIP in elderly is quite widespread, but it is preventable, given that valid explicit criteria for determining improper prescribing of drugs are used in practice, such as Beers, STOPP and START criteria. Purpose. The main objective of this study is to determine the prevalence of PIP on the sample of elderly patients with different degrees of kidney failure and to explore factors that influence rational prescribing of drugs. We used Beers, STOPP and START criteria to identify potentially inadequately prescribed drugs. Methods. The research was performed at the Department of Nephrology, Clinical Center Niš. The data were collected from medical files and patient surveys. The study included a total of 218 patients aged 65 years and over, of which 83 patients (38.1%) were undergoing chronic hemodialysis treatment due to the end stage kidney failure (the first group), while the other 135 patients (61.9% ), with varying degrees of renal insufficiency, was examined in the daily hospital of the Clinic for Nephrology (the second group). Results. The number of patients with potentially inadequately prescribed medication, or medications, did not differ significantly between patients with CKF treated with hemodialysis and those examined in the daily hospital. The main predictors of PIP in our patients were a greater number of co-morbidity and polypharmacy. The patients living in the urban places, the patients with lower levels of education, as well as the patients who did not read the drug instructions, had significantly greater number of PIP’s. Conclusion. Оur study showed that potentially inappropriate prescribing of drugs was frequent phenomenon in both hemodialysis patients and those without renal replacement therapy, present in about a third of patients from both groups. Determining factors that may be associated with the PIP can be of great help in clinical practice in the complex decision-making process. Beleška o autoru: list 115;Bibliografija: listovi 100-114. Datum odbrane: 31.08.2018. Pharmacology with toxicology 1026104045 91552101 6616 91552100 1026104045 2019-02-26T14:12:54.053Z 45 no 46 mentor Gorana G. Nedin Ranković 2018 63 mentor Zorica Jović 2018 63 član komisije Radmila Veličković Radovanović 2018 63 član komisije Slobodan Janković 2018 63 član komisije Srđan Pešić 2018 63 član komisije Branka Mitić 2018 115 listova 3216450 http://phaidrabg.bg.ac.rs/o:1535 no yes 4 2019-02-26T14:12:54.320Z 70 bubrežna insuficijencija, potencijalno neadekvatno propisivanje lekova, Beers kriterijum, STOPP/START kriterijum, stariji pacijenti, hemodijaliza kidney failure, potentially inappropriate prescribing of drugs, Beers criteria,STOPP/START criteria, elderly patients, hemodialysis 615.03:616.61-008.6(043.3) B 740 1738 18A05 18A0530 2018