o:1603 Uticaj indeksa proliferacije KI-67 ćelijskih morfometrijskih paremetara na efekat hemioterapije cisplatinom kod pacijentkinja obolelih od karcinoma grlića materice The influence of KI-67 proliferation index and cell morphometric parameters on the effect of chemiotherapy with cisplatin in patients with cervical cancer : doctoral dissertation sr Cervical cancer is the third most common malignant tumor in the world. Cisplatin is the most commonly used chemotherapeutic agent in the treatment of cervical cancer and is now considered a medication of choice for locally advanced, metastatic and recurrent cervical cancers. To determine the therapeutic protocol in some cancers, it is necessary to determine the Ki-67 proliferation index (Ki-67 PI), while in the treatment of cervical cancer it is still novel. This prospective study included 59 subjects treated at the Clinical Center Niš, with locally advanced cervical cancer, in order to determine the relationship between the therapeutic response to cisplatin and Ki-67 PI, as well as the cell morphometric parameters of the cancer tissue. Survival time in cervical cancer patients is rising with an increase in Ki-67 PI values. The cut off value of Ki-67 PI was determined at 60%, which influenced the statistically significant survival of patients with cervical cancer and represented the sensitivity value of this cancer to chemotherapy with cisplatin. Of the examined cell morphometric parameters, the cell area, perimeter, circularity, Feret diameter, integrated optical density, whose values statistically significantly influenced the length of survival of the subjects, were singled out. Their common use achieves a more reliable prediction of the therapeutic response to cisplatin chemotherapy in patients with cervical cancer, which is the basis of individualization of therapy in these oncology patients. Beleška o autoru: list 155;Bibliografija: listovi 137-154. Datum odbrane: 21.06.2019. Pharmacology with toxicology 1026398957 91552101 7158 91552100 1026398957 2020-01-27T11:03:49.053Z 45 no 46 mentor Dane Krtinić 2019 63 mentor Radomir 1966- Živadinović 2019 63 predsednik komisije Zorica Jović 2019 63 član komisije Srđan Pešić 2019 63 član komisije Dragan Mihailović 2019 63 član komisije Slobodan Janković 2019 155 listova 3401858 http://phaidrabg.bg.ac.rs/o:1603 no yes 4 2020-01-27T11:03:49.320Z 70 cisplatin, terapijski odgovor, indeks proliferacije Ki-67, ćelijski morfometrijski parametri, karcinom grlića materice cisplatin, therapeutic response, Ki-67 proliferation index, cell morphometric parameters, cervical cancer 615.277.03:618.1446-006.6-076(043.3) B740 1738 18A05 18A0520 2019