o:1623 Hemijski sastav, antibakterijska, antioksidativna i genotoksična aktivnost lišajeva Umbilicaria crustulosa (Ach.) Frey, Umbilicaria cylindrica (L.) Delise, Hypogymnia tubulosa (Schaer.) Hav. i Evernia prunastri (L.) Ach. Chemical composition, antibacterial, antioxidant and genotoxic activity of lichens Umbilicaria crustulosa (Аch.) Frey, Umbilicaria cylindrica (L.) Delise, Hypogymnia tubulosa (Schaer.) Hav. and Evernia prunastri (L.) Ach. : doctoral dissertation sr Through this doctoral thesis chemical composition of acetone, ether, ethyl acetate and dichloromethane extracts and antioxidant, antibacterial and genotoxic activity of acetone extracts of the lichens Umbilicaria crustulosa (Аch.) Frey, Umbilicaria cylindrica (L.) Delise, Hypogimnia tubulosa (Schaer.) Hav. and Evernia prunastri (L.) Ach. were examined. Study on the content of the certain elements in these lichens was also carried out. Activity concentration of 40K, 137Cs, 226Ra and 232Th was determined only for lichen E. prunastri. Anticholinesterase activity of acetone extracts and isolated gyrophoric acid was also examined. The most abundant component of acetone extracts of lichen U. crustulosa and U. cylindrica was girophoric acid. The main components of acetone, ether and ethyl acetate extracts of H. tubulosa were physodic acid and the 3-hydroxyphysodic acid. The most abundant component of acetone extract of E. prunastri was evernic acid. The composition of dichloromethane extracts of all investigated lichens was different from the other extracts, atranorine was dominant component fallowed with small quantities of depsides and depsidons. Orcinol, atraric acid and orsellinic acid were the major volatile compounds in U. crustulosa, U. cylindrica and E. prunastri extracts, while olivetol, 3-hydroxyolivetonide and olivetonide were the main volatiles in H. tubulose extracts. Umbilicaria cylindrica has the highest content of Al, Co, Cr, Fe, Mn, V, Ba, Cd and Pb while the content of B, Si and Zn is the largest in U. crustulosa sample. The activity of 40K was 108 Bq kg-1 while the activities of 137Cs, 226Ra and 232Th were below minimal detectable activities. The results of antioxidant activity indicated a higher antioxidant capacity of depsidone compared to the depside. Gram-negative bacteria were resistant to the tested extracts. Extracts of U. cylindrica, E. prunastri and H. tubulosa had inhibition effect towards Gram-positive bacteria. The highest decreasing in the micronucleus frequency were indicated by extracts at concentration of 2 mg mL-1. Extracts of H. tubulosa, E. prunastri and gyrophoric acid at concentration of 10 mg mL-1 showed an inhibitory effect on cholinesterase activity. Biografija sa bibliografijom: str. 126-129;Bibliografija: str. 84-91. Datum odbrane: 13.11.2019. Organic Chemistry and Biochemistry 1025848553 91552101 7240 91552100 1025848553 2020-02-21T12:05:01.053Z 45 no 46 mentor Ivana G. Zlatanović 2019 63 mentor Gordana Stojanović 2019 63 član komisije Violeta Mitić 2019 63 član komisije Andrija Šmelcerović 2019 63 predsednik komisije Olga P. Jovanović 2019 63 član komisije Miroslava Stanković 2019 129 str. 5116212 http://phaidrabg.bg.ac.rs/o:1623 no yes 4 2020-02-21T12:05:01.320Z 70 Umbilicaria crustulosa, Umbilicaria cylindrica, Hypogymnia tubulosa, Evernia prunastri, HPLC, GC-MS, radionuklidi, antioksidativna aktivnost, antibakterijska aktivnost, mikronukleusni test Umbilicaria crustulosa, Umbilicaria cylindrica, Hypogymnia tubulosa, Evernia prunastri, HPLC, GC-MS, antioxidant activity, antibacterial activity, micronucleus test, anticholinesterase activity 581.192:582.29(043.3)615.3:582.29(043.3)615.099:582.29(043.3) P 003, P 390 1738 18A07 18A0703 2019