
<ns0:uwmetadata xmlns:ns0="http://phaidra.univie.ac.at/XML/metadata/V1.0" xmlns:ns1="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0" xmlns:ns10="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0" xmlns:ns11="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0/entity" xmlns:ns12="http://phaidra.univie.ac.at/XML/metadata/digitalbook/V1.0" xmlns:ns13="http://phaidra.univie.ac.at/XML/metadata/etheses/V1.0" xmlns:ns2="http://phaidra.univie.ac.at/XML/metadata/extended/V1.0" xmlns:ns3="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/entity" xmlns:ns4="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/requirement" xmlns:ns5="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/educational" xmlns:ns6="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/annotation" xmlns:ns7="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/classification" xmlns:ns8="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/organization" xmlns:ns9="http://phaidra.univie.ac.at/XML/metadata/histkult/V1.0">
  <ns1:general>
    <ns1:identifier>o:1727</ns1:identifier>
    <ns1:title language="sr">Ispitivanje povezanosti imunohistohemijske ekspresije enzima popravke replikacionih grešaka DNK sa kliničkim i mikromorfološkim karakteristikama kolorektalnog karcinoma</ns1:title>
    <ns2:alt_title language="sr">Immunohistochemical analysis of DNA mismatch repair deficiency in colorectal carcinoma and its association with clinical and micromorphological features : doctoral dissertation</ns2:alt_title>
    <ns1:language>sr</ns1:language>
    <ns1:description language="en">Deficient mismatch repair (MMR) status is associated with good
prognosis but poor therapeutic response to adjuvant chemotherapy in
patients with colorectal cancer. The study enrolled 104 patients
younger than 75 years of age with resected stage II and III colorectal
cancer samples from the period 2018–2019. All
immunohistochemistry analyses were done manually and performed
in the laboratories at the Department of Histology and Embryology,
Faculty of Medicine, University of Niš. The loss of nuclear
expression of at least one MMR protein was recorded in 12 (11.54%)
cases. The tumors with deficient and heterogeneity MMR status were
significantly associated with age up to 50 years and right-sided
localization. This prospective study of a single-center cohort of
patients with stage II and III colorectal cancer highlights the clinical
importance of using immunohistochemistry analysis as a guide for
diagnostic algorithm in a country with limited resources, but with a
high prevalence of colorectal carcinoma in the young patients. MMRdeficiency
tumors compared with proficient MMR colorectal cancer
was not shown to be a significant predictor of disease-free and overall
survival.</ns1:description>
    <ns1:description language="sr">Biografija autora: list 117;Bibliografija: 91-114.  Datum odbrane: 17.03.2021. Pathology</ns1:description>
    <ns2:identifiers>
      <ns2:identifier>36990729</ns2:identifier>
    </ns2:identifiers>
    <ns2:identifiers>
      <ns2:resource>91552101</ns2:resource>
      <ns2:identifier>8231</ns2:identifier>
    </ns2:identifiers>
    <ns2:identifiers>
      <ns2:resource>91552100</ns2:resource>
      <ns2:identifier>36990729</ns2:identifier>
    </ns2:identifiers>
  </ns1:general>
  <ns1:lifecycle>
    <ns1:upload_date>2021-08-24T08:52:35.053Z</ns1:upload_date>
    <ns1:status>45</ns1:status>
    <ns2:peer_reviewed>no</ns2:peer_reviewed>
    <ns1:contribute seq="0">
      <ns1:role>46</ns1:role>
      <ns1:ext_role>mentor</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Tijana 1982-</ns3:firstname>
        <ns3:lastname>Denčić</ns3:lastname>
      </ns1:entity>
      <ns1:date>2021</ns1:date>
    </ns1:contribute>
    <ns1:contribute seq="1">
      <ns1:role>63</ns1:role>
      <ns1:ext_role>mentor</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Miljan 1973-</ns3:firstname>
        <ns3:lastname>Krstić</ns3:lastname>
      </ns1:entity>
      <ns1:date>2021</ns1:date>
    </ns1:contribute>
    <ns1:contribute seq="2">
      <ns1:role>63</ns1:role>
      <ns1:ext_role>predsednik komisije</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Maja 1964-</ns3:firstname>
        <ns3:lastname>Jovičić Milentijević</ns3:lastname>
      </ns1:entity>
      <ns1:date>2021</ns1:date>
    </ns1:contribute>
    <ns1:contribute seq="3">
      <ns1:role>63</ns1:role>
      <ns1:ext_role>član komisije</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Aleksandar 1970-</ns3:firstname>
        <ns3:lastname>Petrović</ns3:lastname>
      </ns1:entity>
      <ns1:date>2021</ns1:date>
    </ns1:contribute>
    <ns1:contribute seq="4">
      <ns1:role>63</ns1:role>
      <ns1:ext_role>član komisije</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Branko 1967-</ns3:firstname>
        <ns3:lastname>Branković</ns3:lastname>
      </ns1:entity>
      <ns1:date>2021</ns1:date>
    </ns1:contribute>
    <ns1:contribute seq="5">
      <ns1:role>63</ns1:role>
      <ns1:ext_role>član komisije</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Nenad 1976-</ns3:firstname>
        <ns3:lastname>Šolajić</ns3:lastname>
      </ns1:entity>
      <ns1:date>2021</ns1:date>
    </ns1:contribute>
  </ns1:lifecycle>
  <ns1:technical>
    <ns1:format>[10], 117 listova</ns1:format>
    <ns1:size>85740585</ns1:size>
    <ns1:location>http://phaidrabg.bg.ac.rs/o:1727</ns1:location>
  </ns1:technical>
  <ns1:rights>
    <ns1:cost>no</ns1:cost>
    <ns1:copyright>yes</ns1:copyright>
    <ns1:license>4</ns1:license>
  </ns1:rights>
  <ns1:annotation>
    <ns6:annotations>
      <ns6:date>2021-08-24T08:52:35.320Z</ns6:date>
    </ns6:annotations>
  </ns1:annotation>
  <ns1:classification>
    <ns1:purpose>70</ns1:purpose>
    <ns7:keyword language="sr" seq="1">Adjuvantna hemioterapija; Deficitarni MMR status; Kolorektalnikarcinom; Imunohistohemijska analiza</ns7:keyword>
    <ns7:keyword language="sr" seq="1">Adjuvant chemotherapy; Deficient mismatch repair status; Colorectalcancer; immunohistochemical analysis</ns7:keyword>
    <ns7:keyword language="sr" seq="1">616.348-006.6:577.175.213.3(043.3)</ns7:keyword>
    <ns7:keyword language="sr" seq="1">B-520</ns7:keyword>
  </ns1:classification>
  <ns1:organization>
    <ns8:hoschtyp>1738</ns8:hoschtyp>
    <ns8:orgassignment>
      <ns8:faculty>18A05</ns8:faculty>
      <ns8:department>18A0518</ns8:department>
    </ns8:orgassignment>
  </ns1:organization>
  <ns12:digitalbook>
    <ns12:releaseyear>2021</ns12:releaseyear>
  </ns12:digitalbook>
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