o:1810 Procena biološke aktivnosti biljne mešavine koja se primenjuje u etnofarmakološkom tretmanu dijabetesa Evaluation of the biological activvity of a herbal mixture used in the ethnopharmacological therapy of diabetes: doctoral dissertation : doctoral dissertation sr Diabetes is one of the most prevalent diseases of the 21st century.Conventional pharmacotherapy of diabetes successfully regulateshyperglycemia, yet it cannot completely prevent the progress ofsecondary diabetic pathologies. Thus, many people combinepharmacotherapy with herbal remedies. This study aimed to evaluatethe frequency of traditional medicine use in Serbia and to examine thebiological activities of the “anti-diabetic” herbal mixture used in theethnopharmacology. The prevalence of traditional medicine use wasassessed by cross-sectional study, while the biological activities of theherbal mixture were examined through in vitro and in vivo experiments.The results of the study showed that 67.7% of respondents from all overSerbia rely on ethnopharmacology. The consumption of polyherbalmixtures and pharmaceutical supplements based on traditional recipeswas more frequent than individual medicinal herbs. Phytochemicalanalysis of tested herbal mixture indicated high content of phenols andflavonoids. The HPLC-UV analysis revealed the presence of tenbioactive compounds: quinic, gallic and caftaric acid, arbutin, rutin,trifolin, astragalin, hyperoside, isoquercetin and quercitrin. In vitrostudy indicated its high antioxidant, anticytotoxic and antigenotoxicactivities as well as antimicrobial activity against a wide range ofmicroorganisms. In addition, its cytotoxicity and genotoxicity wereextremely low. In vivo study showed that this herbal mixture hashypoglycemic, hypolipidemic and hepatoprotective effects in bothhealthy and diabetic animals. Moreover, in diabetic animals, it showednephroprotective activity, while its hypoglycemic effect was higherthan the effect of insulin and metformin in this experimental model. Biografija i bibliografija autora: list. 124-126,Bibliografija: listovi 94-118. Datum odbrane: 03.03.2021. Cell biology. Physiology 91552100 34727689 91552101 8542 2022-11-29T09:35:30.053Z 45 no 46 Višnja, 1984- Madić 52470025 2020 63 mentor Perica, 1972- Vasiljević 13893991 2020 63 član komisije Stevo, 1955- Najman 6868327 2020 63 član komisije Ljubiša, 1961- Đorđević 22793575 2020 63 član komisije Marina, 1969- Jušković 16237927 2020 63 član komisije Gordana, 1960- Stojanović 9679719 2020 129 listova 6442474 http://phaidrani.ni.ac.rs/o:1810 no yes 12 2022-11-29T09:35:30.320Z 70 Dijabetes, biljna mešavina, narodna medicina,citotoksičnost, genotoksičnost, antioksidansi,hipoglikemijski agensi, hepatoprotektivni efekat,nefroprotektivni efekat, hipolipidemijsko dejstvo Diabetes, herbal mixture, traditional medicine, cytotoxicity,genotoxicity, antioxidants, hypoglycemic agents, hepatoprotectiveeffect, nephroprotective effect, hypolipidemic activity 573.6:615.322+615:616.379-008.64 B200; B210; B220; B480; B740 1738 18A07 18A0704 2020