o:1810
Procena biološke aktivnosti biljne mešavine koja se primenjuje u etnofarmakološkom tretmanu dijabetesa
Evaluation of the biological activvity of a herbal mixture used in the ethnopharmacological therapy of diabetes: doctoral dissertation : doctoral dissertation
sr
Diabetes is one of the most prevalent diseases of the 21st century.Conventional pharmacotherapy of diabetes successfully regulateshyperglycemia, yet it cannot completely prevent the progress ofsecondary diabetic pathologies. Thus, many people combinepharmacotherapy with herbal remedies. This study aimed to evaluatethe frequency of traditional medicine use in Serbia and to examine thebiological activities of the “anti-diabetic” herbal mixture used in theethnopharmacology. The prevalence of traditional medicine use wasassessed by cross-sectional study, while the biological activities of theherbal mixture were examined through in vitro and in vivo experiments.The results of the study showed that 67.7% of respondents from all overSerbia rely on ethnopharmacology. The consumption of polyherbalmixtures and pharmaceutical supplements based on traditional recipeswas more frequent than individual medicinal herbs. Phytochemicalanalysis of tested herbal mixture indicated high content of phenols andflavonoids. The HPLC-UV analysis revealed the presence of tenbioactive compounds: quinic, gallic and caftaric acid, arbutin, rutin,trifolin, astragalin, hyperoside, isoquercetin and quercitrin. In vitrostudy indicated its high antioxidant, anticytotoxic and antigenotoxicactivities as well as antimicrobial activity against a wide range ofmicroorganisms. In addition, its cytotoxicity and genotoxicity wereextremely low. In vivo study showed that this herbal mixture hashypoglycemic, hypolipidemic and hepatoprotective effects in bothhealthy and diabetic animals. Moreover, in diabetic animals, it showednephroprotective activity, while its hypoglycemic effect was higherthan the effect of insulin and metformin in this experimental model.
Biografija i bibliografija autora: list. 124-126,Bibliografija: listovi 94-118. Datum odbrane: 03.03.2021. Cell biology. Physiology
91552100
34727689
91552101
8542
2022-11-29T09:35:30.053Z
45
no
46
Višnja, 1984-
Madić
52470025
2020
63
mentor
Perica, 1972-
Vasiljević
13893991
2020
63
član komisije
Stevo, 1955-
Najman
6868327
2020
63
član komisije
Ljubiša, 1961-
Đorđević
22793575
2020
63
član komisije
Marina, 1969-
Jušković
16237927
2020
63
član komisije
Gordana, 1960-
Stojanović
9679719
2020
129 listova
6442474
http://phaidrani.ni.ac.rs/o:1810
no
yes
12
2022-11-29T09:35:30.320Z
70
Dijabetes, biljna mešavina, narodna medicina,citotoksičnost, genotoksičnost, antioksidansi,hipoglikemijski agensi, hepatoprotektivni efekat,nefroprotektivni efekat, hipolipidemijsko dejstvo
Diabetes, herbal mixture, traditional medicine, cytotoxicity,genotoxicity, antioxidants, hypoglycemic agents, hepatoprotectiveeffect, nephroprotective effect, hypolipidemic activity
573.6:615.322+615:616.379-008.64
B200; B210; B220; B480; B740
1738
18A07
18A0704
2020