o:2359 Should Cushing's Syndrome be Considered as a Disease with High Cardiovascular Risk in Relevant Guidelines? en A considerable amount of data supports a 1.8-7.4-fold increased mortality associated with Cushing's syndrome (CS). This is attributed to a high occurrence of several cardiovascular disease (CVD) risk factors in CS [e.g. adiposity, arterial hypertension (AHT), dyslipidaemia and type 2 diabetes mellitus (T2DM)]. Therefore, practically all patients with CS have the metabolic syndrome (MetS), which represents a high CVD risk. Characteristically, despite a relatively young average age, numerous patients with CS display a 'high' or 'very high' CVD risk (i.e. risk of a major CVD event >20% in the following 10 years). Although T2DM is listed as a condition with a high CVD risk, CS is not, despite the fact that a considerable proportion of the CS population will develop T2DM or impaired glucose tolerance. CS is also regarded as a risk factor for aortic dissection in current guidelines. This review considers the evidence supporting listing CS among high CVD risk conditions. Current Vascular Pharmacology vol. 18 br. 1 str. 12-24 Cushing's syndrome; arterial hypertension; cardiovascular risk factors; diabetes mellitus; metabolic syndrome. 1552099 10.2174/1570161116666181005122339 1552101 1570-1611 2024-03-05T22:33:42.217Z 44 yes 46 Goran Koraćević Medicinski fakultet, Univerzitet u Nišu 2019 46 Milan Stojković Medicinski fakultet, Univerzitet u Nišu 46 Dragan Lović Medicinski fakultet, Univerzitet u Nišu 46 Milan Pavlović Medicinski fakultet, Univerzitet u Nišu 46 Tomislav Kostić Medicinski fakultet, Univerzitet u Nišu 46 Marija Kutlešić Medicinski fakultet, Univerzitet u Nišu 46 Slađana Micić Medicinski fakultet, Univerzitet u Nišu 46 Maja Koraćević University of Niš, Faculty of Medicine, Niš, Serbia + University of Niš, Innovation Center, Niš, Serbia 46 Milan Đorđević Health Centre Jagodina, Serbia application/pdf 14395214 https://phaidrani.ni.ac.rs/o:2359 no yes 21 70 92000001 18A15