o:2614 Molekularni mehanizmi ishemijsko-reperfuzionog oštećenja tokom resekcije jetre Molecular mechanisms of hepatic ischemia - reperfusion injury during resection procedures : doctoral dissertation sr Introduction: Bleeding during liver resection is a significant threat to the clinical outcome. The occlusion of the portal triad, inducing complete ischemia of the blood supply to the liver, is a well-documented, safe, and beneficial method for alleviating this problem. Although this technique is effective in limiting blood loss, there are still controversies regarding the potential drawbacks of ischemia and subsequent reperfusion injury to liver tissue. Material and Methods: The prospective study included 30 patients, average age of 62 years, who underwent liver resection surgery due to the neoplastic process or metastases of colorectal cancer. After obtaining informed consent, parameters were analyzed in three phases: preoperative, intraoperative, and postoperative. During the surgery (recommended by the surgeon/oncology board independent of our study), samples of "conditionally healthy liver tissue" (not affected by tumor processes) were taken. Following tissue homogenization, parameters responsible for the onset of liver tissue damage due to ischemia-reperfusion injury (IRI) were analyzed.Ethical standards: Based on the research findings, there were no direct influences noticed on the current clinical procedures, treatment processes, or the final treatment outcome among the patients involved in the study. Nevertheless, the insights obtained from this research may be beneficial for planning and conducting future liver resections in new patients. The analyses derived from this research could offer valuable guidelines for enhancing postoperative care and better understanding the factors impacting patient recovery after resection procedures.Conclusion: Using modern research methods, scientifically validated statistical data analysis, and appropriate literature, significant data about the nature or Biografija autora: list 124Bibliografija: list. 115-122 Datum odbrane: 12.6.2024. Surgery, general surgery 91552100 149798665 91552101 8702 2024-09-03T15:13:30.053Z 45 no 46 Marko, 1984- Gmijović 37748327 2024 63 mentor Miroslav, 1965- Stojanović 9700199 2024 63 član komisije Milan, 1971- Radojković 8307559 2024 63 član komisije Tatjana, 1970- Jevtović-Stoimenov 3893095 2024 63 član komisije Nebojša, 1967- Ignjatović 3463015 2024 63 član komisije Ljiljana, 1969- Milić 73200905 2024 127 listova 3611136 http://phaidrani.ni.ac.rs/o:2614 no yes 12 2024-09-03T15:13:30.320Z 70 Resekcije jetre, transplantacije jetre, ishemijsko reperfuziono oštećenje, metastaze kolorektalnog karcinoma, karcinom jetre, apoptoza, vaskularna izolacija jetre. liver resections, liver transplantations, ischemia-reperfusion injury, metastases of colorectal carcinoma, liver cancer, apoptosis, hepatic vascular isolation. 616.36-006.6-089(043.3) B 600 1738 18A05 18A0525 2024