393 str. 14895463 bytes Filipović, Sonja I. 2025 https://phaidrani.ni.ac.rs/o:3010 cobiss:173008649 thesis:8784 Radulović, Niko, 1981- Dekić, Milan S., 1980- Ranđelović, Pavle, 1980- Nešić, Milan, 1991- Raca, Irena, 1990- srp http://creativecommons.org/licenses/by-nc-nd/3.0/at/legalcode Sekundarni metaboliti odabranih vrsta jetrenjača rodova Porella L. (PORELLACEAE) i conocephalum HILL. (CONOCEPHALACEAE) info:eu-repo/semantics/bachelorThesis In this doctoral dissertation, the chemical composition of essential oils and extracts from three liverworts, two species from the Porellaceae family (Porella platyphylla and Porella cordaeana), as well as the species Conocephalum conicum from the Conocephalaceae family, was investigated. The essential oils were obtained by hydrodistillation, and their analysis was performed by GC-MS. Preparative chromatographic separations of the essential oils and extracts led to the isolation of pure compounds, whose structures were determined by combining spectral methods (1D- and 2D-NMR, GC-MS, FTIR, HRMS, etc.) and chemical transformations. Special attention was given to new natural products, including two derivatives of the pinguisanе skeleton (α-furanopinguisanol and furanopinguisanone), a compound of the lepidozane skeleton ((1Z,4E)-lepidoza-1(10),4-dien-14-ol), and a sesquiterpene diol of the germacrane skeleton with the structure rel-(1(10)Z,4S,5E,7R)-germacra-1(10),5-dien-11,14-diol. Detailed analysis of the NMR spectra identified another new compound, rel-(1(10)Z,4S,5E,7R)-humula-1(10),5-dien-7,14-diol. The biological activity and pharmacological potential of selected secondary metabolites were investigated by various methods on rat lymphocytes. Bibliografija: str. 270-308. Datum odbrane: 02.07.2025. Organic and medicinal chemistry, biochemistry