o:3010 Sekundarni metaboliti odabranih vrsta jetrenjača rodova Porella L. (PORELLACEAE) i conocephalum HILL. (CONOCEPHALACEAE) Secondary metabolites of selected liverworts from the genera porella L. (PORELLACEAE) and conocephalum HILL. (CONOCEPHALACEAE) : doctoral dissertation sr In this doctoral dissertation, the chemical composition of essential oils and extracts from three liverworts, two species from the Porellaceae family (Porella platyphylla and Porella cordaeana), as well as the species Conocephalum conicum from the Conocephalaceae family, was investigated. The essential oils were obtained by hydrodistillation, and their analysis was performed by GC-MS. Preparative chromatographic separations of the essential oils and extracts led to the isolation of pure compounds, whose structures were determined by combining spectral methods (1D- and 2D-NMR, GC-MS, FTIR, HRMS, etc.) and chemical transformations. Special attention was given to new natural products, including two derivatives of the pinguisanе skeleton (α-furanopinguisanol and furanopinguisanone), a compound of the lepidozane skeleton ((1Z,4E)-lepidoza-1(10),4-dien-14-ol), and a sesquiterpene diol of the germacrane skeleton with the structure rel-(1(10)Z,4S,5E,7R)-germacra-1(10),5-dien-11,14-diol. Detailed analysis of the NMR spectra identified another new compound, rel-(1(10)Z,4S,5E,7R)-humula-1(10),5-dien-7,14-diol. The biological activity and pharmacological potential of selected secondary metabolites were investigated by various methods on rat lymphocytes. Bibliografija: str. 270-308. Datum odbrane: 02.07.2025. Organic and medicinal chemistry, biochemistry 91552100 173008649 91552101 8784 2025-10-01T13:21:17.053Z 45 no 46 Sonja I. Filipović 82693641 2025 63 mentor Niko, 1981- Radulović 8429415 2025 63 član komisije Milan S., 1980- Dekić 69160201 2025 63 član komisije Pavle, 1980- Ranđelović 8559719 2025 63 član komisije Milan, 1991- Nešić 109082889 2025 63 član komisije Irena, 1990- Raca 16265063 2025 393 str. 14895463 http://phaidrani.ni.ac.rs/o:3010 no yes 12 2025-10-01T13:21:17.320Z 70 jetrenjača, Porella platyphylla, Porella cordaeana, Conocephalum conicum, etarsko ulje, hromatografija, pingvizani, lepidozani, germakrani, humulani, sinteza, (bio)hemijska povezanost, biološka/farmakološka aktivnost liverwort, Porella platyphylla, Porella cordaeana, Conocephalum conicum, essential oil, chromatography, pinguisanes, lepidozanes, germacranes, humulanes, synthesis, (bio)chemical connection, biological/pharmacological activity 577.121:582.321.1(043.3) P 003, P 390, P 351, P 004 1738 18A07 18A0703 2025