o:3284 Povezanost dermoskopskih karakteristika kutanih metastaza sa patohistološkim parametrima primarnog tumora i kliničkim karakteristikama pacijenata obolelih od melanoma The relationship of dermoscopic characteristics of cutaneous metastases with pathohistological parametres of primary tumor and clinical characteristics of melanoma patients : doctoral dissertation sr This scientific research aims to determine both clinical anddermoscopic characteristics of cutaneous metastases in patients withprimary cutaneous melanoma.Methodology: The dissertation examines the association ofdermoscopic characteristics of cutaneous metastases with thecharacteristics of primary melanoma, its histopathological features andlocalization, as well as the clinical characteristics of melanoma patientsmonitored after surgery at the Clinic for Dermatovenereology of theUniversity Clinical Center Niš, the Clinic for Oncology of theUniversity Clinical Center Niš, and the Clinic for Skin and VenerealDiseases of the Military Medical Academy in Belgrade, in the periodfrom 2020 to 2024. Dermoscopic patterns of cutaneous metastaseswere analyzed. Additionally, the types of structural patterns, additionaldermoscopic characteristics, and the dominant colour were determined.The relationships between the examined parameters were examinedusing statistical data processing.Significance of the research: The majority of cutaneous melanomametastases had a homogeneous pattern (43.8%), followed by a vascular(33.8%), saccular (12.5%), and polymorphic (10%) one. The frequencyof dermoscopic pattern types varied across different clinical types ofcutaneous melanoma metastases (flat and elevated) and betweenpigmented and non-pigmented lesions. Flat cutaneous metastases(macules) predominantly have a homogeneous pattern (72.7%), whileelevated cutaneous metastases (papules and nodules) most often havea vascular pattern (39.7%); the homogeneous pattern is dominant(65.3%) in pigmented cutaneous metastases, while the vascular patternprevails (87.5%) in non-pigmented ones. The type of dermoscopicpattern varies according to the type of primary cutaneous melanoma.In nodular melanoma, the prevailing patterns in its cutaneousmetastases are the homogeneous (46.3%) and vascular (36.6%) ones,while in acral lentiginous melanoma, the vascular pattern of cutaneousmetastases is the most frequent (50%). The presence of additionaldermoscopic characteristics is significantly more common in elevatedthan in flat cutaneous metastases. Non-pigmented cutaneousmetastases show a significantly higher frequency of blood vessels(96.8%) compared with the pigmented ones (32.7%). Mitoses weresignificantly more frequent in the histopathological findings of primarymelanoma in non-pigmented cutaneous metastases. In non-pigmentedmelanoma metastases, the predominant colour is red (77.4%), while inthe pigmented ones, it is blue (51%) and brown (34.7%). Biografija kandidata: list 184Bibliografija: list. 155-183 Datum odbrane: 18.12.2025. Dermatovenerology, Pathology 91552100 190982409 91552101 8835 2026-05-14T13:34:02.053Z 45 no 46 Danijela, 1971- Popović 37084519 2025 63 mentor Danica, 1978- Tiodorović-Živković 10059623 2025 63 mentor Željko, 1969- Mijušković 6163815 2025 63 član komisije Lidija, 1971- Kandolf Sekulović 4231527 2025 63 član komisije Miljan, 1973- Krstić 4934247 2025 63 član komisije Ivan, 1976- Petković 27092071 2025 187 list. 1990799 http://phaidrani.ni.ac.rs/o:3284 no yes 12 2026-05-14T13:34:02.320Z 70 kutane metastaze melanoma, melanom, dermoskopske karakteristike,koža Cutaneous melanoma metastases, melanoma, dermoscopiccharacteristics, skin 616.5-006.81-091.8(043.3) B 200; B 520; B 630; B 725; 1738 18A05 18A0522 2025